ZNF451 Gene

HGNC Family	Zinc fingers
Name	zinc finger protein 451
Description	Enables SUMO ligase activity; transcription corepressor activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in PML body. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZNF451 functions as a multifunctional regulator of protein modification and DNA repair. In the context of DNA damage, particularly in repairing TOP2 cleavage complexes, ZNF451 (also known as ZATT) binds to trapped TOP2–DNA intermediates and facilitates the proteasome‐independent resolution by promoting the recruitment and activation of the tyrosyl-DNA phosphodiesterase TDP2, while its SUMO ligase activity further modulates this process through specific SUMO2-mediated interactions. This dual role in both catalysis of SUMO conjugation and in orchestrating DNA repair underlies its critical function in maintaining genome integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its enzymatic functions, ZNF451 acts as a transcriptional cofactor that modulates nuclear organization and gene regulation. Localized to distinct nuclear compartments such as promyelocytic leukemia bodies, ZNF451 is both a substrate for and an effector of SUMOylation, which governs its compartmentalization and interactions with transcription modulators. Notably, it physically associates with key transcription factors including Smad3/4 and the androgen receptor (AR) to influence transcriptional responses—serving as a corepressor in TGF-β signaling by disrupting p300 recruitment and altering chromatin modifications, as well as participating in the dynamic trafficking of transcription regulators within the nucleus."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, the role of ZNF451 extends into oncogenesis and cancer therapy resistance. In pancreatic ductal adenocarcinoma, decreased ZNF451 expression (mediated by the lncRNA BC032020) correlates with reduced tumor cell proliferation and migration, suggesting that ZNF451 supports tumor cell survival in this context. Conversely, in triple-negative breast cancer, elevated levels of ZNF451 promote tumor progression by interacting with SLUG to enhance the transcription of oncogenic factors such as CCL5, thereby modulating the tumor microenvironment through the activation of tumor-associated macrophages. Furthermore, a circular RNA derived from the ZNF451 locus (circZNF451) has been implicated in resistance to PD1 blockade in lung adenocarcinoma, highlighting additional layers of regulatory complexity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Matthew J Schellenberg, Jenna Ariel Lieberman, Andrés Herrero-Ruiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aam6468"}], "href": "https://doi.org/10.1126/science.aam6468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28912134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28912134"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Laurent Cappadocia, Andrea Pichler, Christopher D Lima "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3116"}], "href": "https://doi.org/10.1038/nsmb.3116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26524494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26524494"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ulla Karvonen, Tiina Jääskeläinen, Miia Rytinki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2008.07.016"}], "href": "https://doi.org/10.1016/j.jmb.2008.07.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18656483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18656483"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yili Feng, Hongxing Wu, Yongxian Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.526905"}], "href": "https://doi.org/10.1074/jbc.M113.526905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24324267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24324267"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhipeng Zhang, Hongxi Chen, Yebin Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA BC032020 suppresses the survival of human pancreatic ductal adenocarcinoma cells by targeting ZNF451."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4289"}], "href": "https://doi.org/10.3892/ijo.2018.4289"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29532883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29532883"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jian Gao, Yong-Qiang Ao, Ling-Xian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-022-02505-z"}], "href": "https://doi.org/10.1186/s13046-022-02505-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36209117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36209117"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Zhang, Wanyu Wang, Jiali Min, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2023.112654"}], "href": "https://doi.org/10.1016/j.celrep.2023.112654"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37342906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37342906"}]}]}]}
Synonyms	DJ417I1.1, COASTER
Proteins	ZN451_HUMAN
NCBI Gene ID	26036
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ZNF451 has 6,447 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 108 datasets.

Click the + buttons to view associations for ZNF451 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ZNF451 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZNF451 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ZNF451 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ZNF451 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ZNF451 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZNF451 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF451 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZNF451 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZNF451 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ZNF451 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZNF451 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF451 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ZNF451 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF451 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ZNF451 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ZNF451 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ZNF451 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ZNF451 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ZNF451 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ZNF451 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ZNF451 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ZNF451 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ZNF451 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZNF451 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ZNF451 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ZNF451 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ZNF451 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ZNF451 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ZNF451 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ZNF451 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ZNF451 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ZNF451 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ZNF451 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF451 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ZNF451 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ZNF451 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF451 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ZNF451 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ZNF451 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ZNF451 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of ZNF451 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.