{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided collection of abstracts spans many facets of immune regulation—detailing how precise modulation of tyrosine phosphorylation, via signaling molecules such as the phosphatase SHP‐1 and its associated partners, is essential for establishing activation thresholds in T and B lymphocytes, for restraining inflammatory responses in macrophages and mast cells, and for governing other processes such as cell‐cycle quiescence in stem cells—none of these studies mention or investigate ZNF697. In these reports, investigators interrogate the roles of negative feedback regulators in antigen receptor signaling, cytokine responsiveness, and inflammatory disease, yet there is no evidence that ZNF697 participates in these pathways or contributes to the control of immune cell activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n \nDespite the extensive investigation into the molecular circuitry that governs immune activation, antigen receptor signaling fidelity, and inflammatory regulation across a range of cell types, the functional role of ZNF697 is not addressed in any of these studies. Consequently, determining whether ZNF697 plays a role in these or related signaling pathways awaits future inquiry."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vicki C J Fawcett, Ulrike Lorenz "}, {"type": "b", "children": [{"type": "t", "text": "Localization of Src homology 2 domain-containing phosphatase 1 (SHP-1) to lipid rafts in T lymphocytes: functional implications and a role for the SHP-1 carboxyl terminus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.174.5.2849"}], "href": "https://doi.org/10.4049/jimmunol.174.5.2849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15728495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15728495"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer D Carter, Gina M Calabrese, Makoto Naganuma, et al. 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