| HGNC Family | Zinc fingers |
| Name | zinc finger protein 891 |
| Description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that the regulation of interferon‐epsilon (IFN‑ε) is unique among type I interferons. Unlike the inducible interferons that respond to pathogen‐associated signals, IFN‑ε is constitutively expressed in epithelial cells and is regulated by cell‐specific transcription factors and hormonal cues. In particular, IFN‑ε expression in reproductive tract epithelia is driven by the epithelial-restricted transcription factor Elf3, and its expression and secretion appear to depend on specialized cofactors—this might also explain its cross-talk with estrogen signaling in antigen-presenting cells during immunoregulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, IFN‑ε distinguishes itself from other type I interferons by its pattern of expression. It is constitutively produced in both female and male reproductive tracts in a hormonally regulated manner, rather than being induced via traditional pathogen detection pathways. This steady-state production creates a preemptive antiviral and immunoregulatory environment that protects against common sexually transmitted infections, such as herpes simplex virus 2 and Chlamydia muridarum."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the reproductive organs, IFN‑ε plays an important role in mucosal immunity. Studies using intranasal infection models have shown that IFN‑ε mediates rapid viral clearance in the lung, enhances the recruitment and activation of specific T-cell subsets, and even promotes the migration of antigen-specific CD8⁺ T cells to gut-associated lymphoid tissues. These mucosal actions suggest that IFN‑ε could serve as a powerful local immune mediator capable of countering infections such as Zika virus and potentially other pathogens that exploit mucosal entry points."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tomasz Maj, Anna S Awek, Katarzyna Kaleta-Kuratewicz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "17β-Estradiol and interferon tau interact in the regulation of the immune response in a model of experimental autoimmune orchitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Interferon Cytokine Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/jir.2010.0147"}], "href": "https://doi.org/10.1089/jir.2010.0147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21787220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21787220"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ka Yee Fung, Eveline D de Geus, Le Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Interferon Epsilon in Mucosal Epithelium is Regulated by Elf3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10985549.2024.2366207"}], "href": "https://doi.org/10.1080/10985549.2024.2366207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38975675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38975675"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ka Yee Fung, Niamh E Mangan, Helen Cumming, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-ε protects the female reproductive tract from viral and bacterial infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1233321"}], "href": "https://doi.org/10.1126/science.1233321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23449591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23449591"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Pascale Hermant, Cédric Francius, Frédéric Clotman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IFN-ε is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0071320"}], "href": "https://doi.org/10.1371/journal.pone.0071320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23951133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23951133"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yang Xi, Stephanie L Day, Ronald J Jackson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of novel type I interferon epsilon in viral infection and mucosal immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mi.2012.35"}], "href": "https://doi.org/10.1038/mi.2012.35"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22617838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22617838"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rosa C Coldbeck-Shackley, Ornella Romeo, Sarah Rosli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1010843"}], "href": "https://doi.org/10.1371/journal.ppat.1010843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36897927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36897927"}]}]}]}
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| Proteins | ZN891_HUMAN |
| NCBI Gene ID | 101060200 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ZNF891 has 1,187 functional associations with biological entities spanning 7 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 46 datasets.
Click the + buttons to view associations for ZNF891 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF891 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF891 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ZNF891 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ZNF891 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing ZNF891 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ZNF891 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with ZNF891 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by ZNF891 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with ZNF891 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ZNF891 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with ZNF891 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZNF891 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving ZNF891 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving ZNF891 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ZNF891 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing ZNF891 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing ZNF891 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by ZNF891 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by ZNF891 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by ZNF891 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of ZNF891 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ZNF891 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ZNF891 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF891 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ZNF891 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with ZNF891 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with ZNF891 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with ZNF891 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF891 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of ZNF891 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of ZNF891 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF891 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for ZNF891 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ZNF891 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of ZNF891 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF891 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZNF891 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZNF891 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of ZNF891 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF891 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ZNF891 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ZNF891 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of ZNF891 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of ZNF891 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF891 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ZNF891 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
