Small molecules which mimic Lewy body dementia
Canned Analysis
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General Information
AccessionDCA00009426
TitleSmall molecules which mimic Lewy body dementia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the Lewy body dementia gene expression signature in the Substantia nigra - Braak α-synuclein stage 1-2 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1cc59e467bea600fb8adc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:1067
Cell TypeSubstantia nigra - Braak α-synuclein stage 1-2
DO IDDOID:12217
Disease NameLewy body dementia
Organismhuman
UMLS CUIC0752347
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1192691, GSM1192692, GSM1192693, GSM1192694, GSM1192695, GSM1192696, GSM1192697, GSM1192698
Perturbed SamplesGSM1192699, GSM1192700, GSM1192701, GSM1192702, GSM1192703
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE49036
Gene Expression Omnibus
Evidence for immune response, axonal dysfunction and reduced endocytosis preceding Lewy body pathology in the substantia nigra in Parkinsons disease
21
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