Small molecules which reverse Methotrexate treatment
Canned Analysis
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General Information
AccessionDCA00011987
TitleSmall molecules which reverse Methotrexate treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Methotrexate treatment in the HT29 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d1f6e467bea600fb8d76
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatoralanstern
CREEDS IDdrug:2543
Cell TypeHT29
Drug NameMethotrexate
DrugBank IDDB00563
Organismhuman
PubChem CID126941
SMILES IDCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM288491, GSM288497, GSM288499
Perturbed SamplesGSM288501, GSM288502, GSM288536
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11440
Gene Expression Omnibus
Methotrexate-resistant HT29 colon adenocarcinoma cell line
12
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