Small molecules which mimic Doxorubicin treatment
Canned Analysis
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General Information
AccessionDCA00012322
TitleSmall molecules which mimic Doxorubicin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Doxorubicin treatment.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ed1ae467bea600fb996e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2724
Drug NameDoxorubicin
DrugBank IDDB00997
Organismhuman
PubChem CID31703
SMILES IDCC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM11706, GSM11853
Perturbed SamplesGSM11731, GSM11839
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE763
Gene Expression Omnibus
Breast cancer cell line ZR-75-1 response to chemotherapeutics: time course
28
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