Small molecules which reverse Troglitazone treatment
Canned Analysis
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General Information
AccessionDCA00012461
TitleSmall molecules which reverse Troglitazone treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Troglitazone treatment in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e88ce467bea600fb976c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2833
Cell Typeliver
Drug NameTroglitazone
DrugBank IDDB00197
Organismrat
SMILES IDO=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCc2c(O1)c(C)c(c(c2C)O)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM533008, GSM533009, GSM533010
Perturbed SamplesGSM533020, GSM533021, GSM533022
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE21329
Gene Expression Omnibus
Peroxisome proliferator-activated receptor- ligand treatment: adipose tissue, skeletal muscle, and liver
42
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