Small molecules which mimic Troglitazone treatment
Canned Analysis
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General Information
AccessionDCA00012462
TitleSmall molecules which mimic Troglitazone treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Troglitazone treatment in the skeletal muscle cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e6eae467bea600fb96b4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2834
Cell Typeskeletal muscle
Drug NameTroglitazone
DrugBank IDDB00197
Organismrat
SMILES IDO=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCc2c(O1)c(C)c(c(c2C)O)C
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM533026, GSM533027, GSM533028
Perturbed SamplesGSM533038, GSM533039, GSM533040
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE21329
Gene Expression Omnibus
Peroxisome proliferator-activated receptor- ligand treatment: adipose tissue, skeletal muscle, and liver
42
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