Small molecules which reverse Angiotensin ii treatment
Canned Analysis
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General Information
AccessionDCA00012781
TitleSmall molecules which reverse Angiotensin ii treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Angiotensin ii treatment in the Heart (PKCζ - Knockout) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1eb9de467bea600fb98c0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3217
Cell TypeHeart (PKCζ - Knockout)
Drug NameAngiotensin ii
Organismmouse
PubChem CID172198
SMILES IDCCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM721519, GSM721520, GSM721521
Perturbed SamplesGSM721517, GSM721518
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29145
Gene Expression Omnibus
Protein kinase C (PKC) knockout response to chronic angiotensin treatment in vivo: heart
38
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