Small molecules which reverse Phorbol 12-myristate 13-acetate (pma) treatment
Canned Analysis
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General Information
AccessionDCA00012817
TitleSmall molecules which reverse Phorbol 12-myristate 13-acetate (pma) treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Phorbol 12-myristate 13-acetate (pma) treatment in the Cell lines U937-ZXD family zinc finger C cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e51de467bea600fb95ee
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorjustinenoel
CREEDS IDdrug:3246
Cell TypeCell lines U937-ZXD family zinc finger C
Drug NamePhorbol 12-myristate 13-acetate (pma)
Organismhuman
PubChem CID27924
SMILES IDCCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1103973, GSM1103977, GSM1103981
Perturbed SamplesGSM1103975, GSM1103979, GSM1103983
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE45417
Gene Expression Omnibus
Zinc finger transcription factor ZXDC depletion effect on myeloid cell line undergoing differentiation
35
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