Small molecules which reverse Cyclophosphamide treatment
Canned Analysis
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General Information
AccessionDCA00013441
TitleSmall molecules which reverse Cyclophosphamide treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Cyclophosphamide treatment in the Pancreatic islets (from BDC2.5/NOD transgenics) - 200 mg/kg - 2 Day after treatment cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dfc7e467bea600fb9392
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3627
Cell TypePancreatic islets (from BDC2.5/NOD transgenics) - 200 mg/kg - 2 Day after treatment
Drug NameCyclophosphamide
DrugBank IDDB00531
Organismmouse
PubChem CID2907
SMILES IDC1CNP(=O)(OC1)N(CCCl)CCCl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM41439, GSM41440, GSM41441, GSM41442, GSM41443, GSM41444, GSM41445, GSM41446
Perturbed SamplesGSM41451, GSM41452, GSM41453
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE2254
Gene Expression Omnibus
Type 1 diabetes model response to cyclophosphamide: time course
28
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