Type 1 diabetes model response to cyclophosphamide: time course
Transcriptomics Dataset
FAIR Metrics
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General Information
AccessionGSE2254
TitleType 1 diabetes model response to cyclophosphamide: time course
DescriptionAnalysis of pancreatic islets from BDC2.5/NOD transgenics after treatment with 200 mg/kg cyclophosphamide (CY) at various time points up to 3 days. CY induces diabetes in BDC2.5/NOD transgenics. Results provide insight into molecular events accompanying the progression from insulitis to diabetes.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2254
RepositoryGene Expression Omnibus
Tools used to analyze the dataset

Keyword
Dataset Accession

Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset

Dataset Accession
Tool Name
Direction
Cell Type
Geneset

Small molecules which mimic Cyclophosphamide treatment
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse Cyclophosphamide treatment
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic Cyclophosphamide treatment
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse Cyclophosphamide treatment
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic Cyclophosphamide treatment
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse Cyclophosphamide treatment
The L1000 database was queried in order to identify small molecule perturbations which rev...
Enrichment analysis of genes dysregulated following Cyclophosphamide treatment
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated following Cyclophosphamide treatment
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated following Cyclophosphamide treatment
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Interaction network and enrichment analysis of genes downregulated in type 1 diabetes mellitus
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
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