Small molecules which reverse IL10 KO
Canned Analysis
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General Information
AccessionDCA00019840
TitleSmall molecules which reverse IL10 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IL10 KO in the Colon epithelium, 6 weeks of age cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22c6be467bea600fbb4d6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1098
Cell TypeColon epithelium, 6 weeks of age
Gene Symbol (human)IL10
Gene Symbol (mouse)Il10
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM980474, GSM980477, GSM980480, GSM980485, GSM980487, GSM980491
Perturbed SamplesGSM980472, GSM980475, GSM980482, GSM980484, GSM980490, GSM980493
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39859
Gene Expression Omnibus
Gene expression changes in the microdissected colon epithelium are similar to those of intact colon in the Il10-/- mouse model of IBD
28
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