Small molecules which mimic AIRE NULL MUTATION
Canned Analysis
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General Information
AccessionDCA00019979
TitleSmall molecules which mimic AIRE NULL MUTATION
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by AIRE NULL MUTATION in the Medullary epithelial cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21b35e467bea600fbad70
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1172
Cell TypeMedullary epithelial cells
Gene Symbol (human)AIRE
Gene Symbol (mouse)Aire
Organismmouse
Perturbation TypeNULL MUTATION
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM304908, GSM304909, GSM304910
Perturbed SamplesGSM304911, GSM304912, GSM304913
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12073
Gene Expression Omnibus
Aire ectopic expression effect on pancreatic islet beta cells
14
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