Small molecules which mimic AIRE Ectopic expression - (transgenic AIRE overexpression)
Canned Analysis
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General Information
AccessionDCA00019981
TitleSmall molecules which mimic AIRE Ectopic expression - (transgenic AIRE overexpression)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by AIRE Ectopic expression - (transgenic AIRE overexpression) in the Pancreatic islet beta cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21b2be467bea600fbad6c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1173
Cell TypePancreatic islet beta cells
Gene Symbol (human)AIRE
Gene Symbol (mouse)Aire
Organismmouse
Perturbation TypeEctopic expression - (transgenic AIRE overexpression)
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM304902, GSM304903, GSM304904
Perturbed SamplesGSM304905, GSM304906, GSM304907
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE12073
Gene Expression Omnibus
Aire ectopic expression effect on pancreatic islet beta cells
14
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