Small molecules which reverse H3F3A Mutation (K27M - mutation of key residues in histone H3.3)
Canned Analysis
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General Information
AccessionDCA00020086
TitleSmall molecules which reverse H3F3A Mutation (K27M - mutation of key residues in histone H3.3)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by H3F3A Mutation (K27M - mutation of key residues in histone H3.3) in the Pediatric glioblastoma (GBM) tumors cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22fafe467bea600fbb646
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1229
Cell TypePediatric glioblastoma (GBM) tumors
Gene Symbol (human)H3F3A
Organismhuman
Perturbation TypeMutation (K27M - mutation of key residues in histone H3.3)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM855946, GSM855948, GSM855949, GSM855950, GSM855951, GSM855952, GSM855953, GSM855954, GSM855955, GSM855956, GSM855958, GSM855959, GSM855960, GSM855961, GSM855962, GSM855963, GSM855964, GSM855965
Perturbed SamplesGSM855947, GSM855957, GSM855966, GSM855967, GSM855968
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE34824
Gene Expression Omnibus
Pediatric glioblastoma brain tumors: histone H3.3 mutations
14
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