Pediatric glioblastoma brain tumors: histone H3.3 mutations
Transcriptomics Dataset
FAIR Metrics
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General Information
AccessionGSE34824
TitlePediatric glioblastoma brain tumors: histone H3.3 mutations
DescriptionAnalysis of pediatric glioblastoma (GBM) tumors with mutations in H3F3A gene. Mutation of key residues in histone H3.3 are specific to GBM and highly prevalent in children and young adults. Results indicate that defects in chromatin architecture underlie pediatric GBM pathogenesis.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE34824
RepositoryGene Expression Omnibus
Tools used to analyze the dataset
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset
Filters  
Dataset Accession
Tool Name
Direction
Pert Type
Geneset
Small molecules which mimic H3F3A Mutation (G34R - mutation of key residues in histone H3.3)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse H3F3A Mutation (G34R - mutation of key residues in histone H3.3)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic H3F3A Mutation (K27M - mutation of key residues in histone H3.3)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse H3F3A Mutation (K27M - mutation of key residues in histone H3.3)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Enrichment analysis of genes dysregulated in H3F3A Mutation (G34R - mutation of key residues in histone H3.3)
PAEA, Characteristic Direction
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated in H3F3A Mutation (K27M - mutation of key residues in histone H3.3)
PAEA, Characteristic Direction
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Interaction network and enrichment analysis of genes downregulated in H3F3A Mutation (G34R - mutation of key residues in histone H3.3)
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in H3F3A Mutation (G34R - mutation of key residues in histone H3.3)
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes downregulated in H3F3A Mutation (K27M - mutation of key residues in histone H3.3)
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in H3F3A Mutation (K27M - mutation of key residues in histone H3.3)
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
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