Small molecules which mimic NFE2L2 KO
Canned Analysis
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General Information
AccessionDCA00020167
TitleSmall molecules which mimic NFE2L2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by NFE2L2 KO in the Lung 5 month high smoke exposure plus 1 day recovery cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f756e467bea600fb9dea
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcms
CREEDS IDgene:1261
Cell TypeLung 5 month high smoke exposure plus 1 day recovery
Gene Symbol (human)NFE2L2
Gene Symbol (mouse)Nfe2l2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM457979, GSM457980, GSM457981, GSM457982
Perturbed SamplesGSM457995, GSM457996, GSM457997, GSM457998
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE18344
Gene Expression Omnibus
Nrf2-deficient lung response to cigarette smoke: dose response and time course
98
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