Nrf2-deficient lung response to cigarette smoke: dose response and time course
Transcriptomics Dataset
FAIR Metrics
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General Information
AccessionGSE18344
TitleNrf2-deficient lung response to cigarette smoke: dose response and time course
DescriptionAnalysis of lungs from transcription factor Nrf2-deficient animals exposed to cigarette smoke (CS) at various doses and for various lengths of time with or without a subsequent recovery period. Results provide insight into the impact of Nrf2 in acute and subchronic smoking scenarios.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18344
RepositoryGene Expression Omnibus
Tools used to analyze the dataset

Keyword
Dataset Accession

Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset

Dataset Accession
Tool Name
Direction
Cell Type
Geneset

Small molecules which mimic NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse NFE2L2 KO
The L1000 database was queried in order to identify small molecule perturbations which rev...
...
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