Small molecules which reverse PIAS1 Null mutation (IFN-beta agent treatment, 2/4 hours)
Canned Analysis
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General Information
AccessionDCA00020414
TitleSmall molecules which reverse PIAS1 Null mutation (IFN-beta agent treatment, 2/4 hours)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PIAS1 Null mutation (IFN-beta agent treatment, 2/4 hours) in the mouse immune system cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d225c6e467bea600fbb1e2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsolomoniyi
CREEDS IDgene:1377
Cell Typemouse immune system
Gene Symbol (human)PIAS1
Gene Symbol (mouse)Pias1
Organismmouse
Perturbation TypeNull mutation (IFN-beta agent treatment, 2/4 hours)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM26691, GSM26692
Perturbed SamplesGSM26686, GSM26687
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1552
Gene Expression Omnibus
Interferon signaling in PIAS1 null mutants: time course
14
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