Interferon signaling in PIAS1 null mutants: time course
Transcriptomics Dataset
FAIR Metrics
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General Information
AccessionGSE1552
TitleInterferon signaling in PIAS1 null mutants: time course
DescriptionExpression profiling of bone marrow derived macrophages of PIAS1 null mutants treated with 500 U/ml interferon (IFN)-beta or 10 ng/ml IFN-gamma for 2 and 4 hours. IFN activates the STAT pathway, which is negatively regulated by PIAS1. Antiviral activity of IFN is enhanced in PIAS1 nulls.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1552
RepositoryGene Expression Omnibus
Tools used to analyze the dataset
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset
Filters  
Dataset Accession
Tool Name
Direction
Pert Type
Geneset
Small molecules which mimic PIAS1 Null mutation (IFN-beta agent treatment, 2/4 hours)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse PIAS1 Null mutation (IFN-beta agent treatment, 2/4 hours)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic PIAS1 Null mutation (IFN-gamma agent treatment, 2/4 hours)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse PIAS1 Null mutation (IFN-gamma agent treatment, 2/4 hours)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Enrichment analysis of genes dysregulated in PIAS1 Null mutation (IFN-beta agent treatment, 2/4 hours)
PAEA, Characteristic Direction
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated in PIAS1 Null mutation (IFN-gamma agent treatment, 2/4 hours)
PAEA, Characteristic Direction
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Interaction network and enrichment analysis of genes downregulated in PIAS1 Null mutation (IFN-beta agent treatment, 2/4 hours)
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in PIAS1 Null mutation (IFN-beta agent treatment, 2/4 hours)
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes downregulated in PIAS1 Null mutation (IFN-gamma agent treatment, 2/4 hours)
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in PIAS1 Null mutation (IFN-gamma agent treatment, 2/4 hours)
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
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