Small molecules which mimic LMO3 KD
Canned Analysis
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General Information
AccessionDCA00021099
TitleSmall molecules which mimic LMO3 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by LMO3 KD in the human adipose stem cells were transfected with a control siRNA (siCtrl) or siRNA oligos targeting the gene LMO3. 40Hrs later, the transfected human adipose stem cells were induced to differentiate into mature adipocytes with a adipogenic cocktail (FullMix) and RNA isolated at day 6 after induction of differentiation. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22b90e467bea600fbb474
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1788
Cell Typehuman adipose stem cells were transfected with a control siRNA (siCtrl) or siRNA oligos targeting the gene LMO3. 40Hrs later, the transfected human adipose stem cells were induced to differentiate into mature adipocytes with a adipogenic cocktail (FullMix
Gene Symbol (human)LMO3
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1023027, GSM1023028
Perturbed SamplesGSM1023029, GSM1023030
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE41712
Gene Expression Omnibus
Expression data from mock- or LMO3 silenced differentiating adipose stem cells
28
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