Small molecules which reverse HTT Mutation (HTT exon1 18Q)
Canned Analysis
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General Information
AccessionDCA00021840
TitleSmall molecules which reverse HTT Mutation (HTT exon1 18Q)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HTT Mutation (HTT exon1 18Q) in the Cerebellum- X50 mice (16 months) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d206f1e467bea600fba48a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2285
Cell TypeCerebellum- X50 mice (16 months)
Gene Symbol (human)HTT
Gene Symbol (mouse)Htt
Organismmouse
Perturbation TypeMutation (HTT exon1 18Q)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM73192, GSM73196, GSM73197
Perturbed SamplesGSM73193, GSM73194, GSM73195
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3248
Gene Expression Omnibus
Nuclear and extranuclear mutant huntingtin exon 1 protein effect on cerebellum
86
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