Nuclear and extranuclear mutant huntingtin exon 1 protein effect on cerebellum
Transcriptomics Dataset
FAIR Metrics
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General Information
AccessionGSE3248
TitleNuclear and extranuclear mutant huntingtin exon 1 protein effect on cerebellum
DescriptionAnalysis of cerebella of transgenics expressing mutant huntingtin (htt) exon 1 protein in nucleus only or in both nucleus and cytoplasm. The polyglutamine (polyQ) expansion in htt results in Huntington's disease (HD). Results provide insight into the impact of subcellular location of polyQ in HD.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE3248
RepositoryGene Expression Omnibus
Tools used to analyze the dataset
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset
Filters  
Dataset Accession
Tool Name
Organism
Direction
Cell Type
Pert Type
Geneset
Small molecules which mimic HTT Mutation (HTT exon1 142Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse HTT Mutation (HTT exon1 142Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic HTT Mutation (HTT exon1 142Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse HTT Mutation (HTT exon1 142Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic HTT Mutation (HTT exon1 142Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse HTT Mutation (HTT exon1 142Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic HTT Mutation (HTT exon1 18Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse HTT Mutation (HTT exon1 18Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic HTT Mutation (HTT exon1 142Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse HTT Mutation (HTT exon1 142Q)
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
...
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