Small molecules which reverse HTT Mutation (HTT exon1 142Q)
Canned Analysis
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General Information
AccessionDCA00021842
TitleSmall molecules which reverse HTT Mutation (HTT exon1 142Q)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HTT Mutation (HTT exon1 142Q) in the Cerebellum - A39 Mice (4 months) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20770e467bea600fba4c2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2286
Cell TypeCerebellum - A39 Mice (4 months)
Gene Symbol (human)HTT
Gene Symbol (mouse)Htt
Organismmouse
Perturbation TypeMutation (HTT exon1 142Q)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM73200, GSM73218, GSM73221, GSM73231
Perturbed SamplesGSM73219, GSM73220, GSM73232, GSM73233
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE3248
Gene Expression Omnibus
Nuclear and extranuclear mutant huntingtin exon 1 protein effect on cerebellum
86
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