Small molecules which reverse MECP2 KD
Canned Analysis
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General Information
AccessionDCA00023278
TitleSmall molecules which reverse MECP2 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MECP2 KD in the E16 primary cortical neuron cultures cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2105ae467bea600fba8b2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:361
Cell TypeE16 primary cortical neuron cultures
Gene Symbol (human)MECP2
Gene Symbol (mouse)Mecp2
Organismmouse
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1145942, GSM1145943, GSM1145944
Perturbed SamplesGSM1145764, GSM1145765, GSM1145766, GSM1145767
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE47150
Gene Expression Omnibus
Embryonic primary cortical neuron response to knockdown of multiple autism candidate genes
112
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