Embryonic primary cortical neuron response to knockdown of multiple autism candidate genes
Transcriptomics Dataset
FAIR Metrics
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General Information
AccessionGSE47150
TitleEmbryonic primary cortical neuron response to knockdown of multiple autism candidate genes
DescriptionAnalysis of E16 primary cortical neuron cultures transduced with shRNA constructs of austism spectrum disorder (ASD)-implicated genes (ACGs): Mecp2, Mef2a, Mef2d, Fmr1, Nlgn1, Nlgn3, Pten, and Shank3. Results provide insight into common transcriptional networks underlying autism.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE47150
RepositoryGene Expression Omnibus
Tools used to analyze the dataset

Keyword
Dataset Accession

Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset

Dataset Accession
Tool Name
Direction
Cell Type
Hs Gene Symbol
Mm Gene Symbol
Geneset

Small molecules which mimic FMR1 KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse FMR1 KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic MECP2 KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse MECP2 KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic NLGN1 KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse NLGN1 KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic NLGN3 KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse NLGN3 KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic PTEN KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse PTEN KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
...
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