Small molecules which reverse ESR1 KD
Canned Analysis
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General Information
AccessionDCA00023424
TitleSmall molecules which reverse ESR1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ESR1 KD in the MCF7 breast cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21606e467bea600fbab2a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:480
Cell TypeMCF7 breast cancer cells
Gene Symbol (human)ESR1
Gene Symbol (mouse)Esr1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM678802, GSM678803, GSM678804
Perturbed SamplesGSM678805, GSM678806, GSM678807
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE27473
Gene Expression Omnibus
Estrogen receptor alpha-silenced MCF7 breast cancer cells
7
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