Small molecules which reverse NFE2L2 Mutation
Canned Analysis
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General Information
AccessionDCA00023610
TitleSmall molecules which reverse NFE2L2 Mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by NFE2L2 Mutation in the Skin cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2375ee467bea600fbb9a8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvmathur
CREEDS IDgene:624
Cell TypeSkin
Gene Symbol (human)NFE2L2
Gene Symbol (mouse)Nfe2l2
Organismmouse
Perturbation TypeMutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM862835, GSM862836, GSM862837
Perturbed SamplesGSM862838, GSM862839, GSM862840
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE35160
Gene Expression Omnibus
Transcription factor Nrf2 gain-of-function model: postnatal day 2.5 whole skin
7
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