Interaction network and enrichment analysis of genes upregulated in amyotrophic lateral sclerosis
Canned Analysis
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General Information
AccessionDCA00032740
TitleInteraction network and enrichment analysis of genes upregulated in amyotrophic lateral sclerosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by amyotrophic lateral sclerosis and healthy control cells in the Spinal cord grey matter - sporadic ALS cell type.
Analysis URLhttp://genemania.org/#/search/human/MT2A|MT1HL1|NPIPB5|APOE|FTL|VIM|CD74|LOC100130553|PSAP|RPSAP19|GNAS|RPLP2|RPLP1|IFITM2|RPS25|RPS16|RPLP0|RPL23AP74|RPL4|B2M|RPS15|IFITM1|RPL18A|CD99|RPL19
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:1006
Cell TypeSpinal cord grey matter - sporadic ALS
DO IDDOID:332
Disease Nameamyotrophic lateral sclerosis
Organismhuman
UMLS CUIC0002736
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM6826, GSM6829, GSM6830, GSM6831
Perturbed SamplesGSM6827, GSM6828, GSM6834, GSM6835, GSM6836
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE833
Gene Expression Omnibus
Amyotrophic lateral sclerosis (Lou Gehrig's Disease)
14
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