GeneMANIA
Computational Tool
FAIR Metrics
0 evaluations
General Information
DescriptionBiological network integration for gene prioritization and predicting gene function
Homepagehttp://www.genemania.org
Publications
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
David Warde-Farley; Sylva L. Donaldson; Ovi Comes; Khalid Zuberi; Rashad Badrawi; Pauline Chao; Max Franz; Chris Grouios; Farzana Kazi; Christian Tannus Lopes; Anson Maitland; Sara Mostafavi; Jason Montojo; Quentin Shao; George Wright; Gary D. Bader; Quaid Morris
GeneMANIA (http://www.genemania.org) is a flexible, user-friendly web interface for generating hypotheses about gene function, analyzing gene lists and prioritizing genes for functional assays. Given a query list, GeneMANIA extends the list with functionally similar genes that it identifies using available genomics and proteomics data. GeneMANIA also reports weights that indicate the predictive value of each selected data set for the query. Six organisms are currently supported (Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Homo sapiens and Saccharomyces cerevisiae) and hundreds of data sets have been collected from GEO, BioGRID, Pathway Commons and I2D, as well as organism-specific functional genomics data sets. Users can select arbitrary subsets of the data sets associated with an organism to perform their analyses and can upload their own data sets to analyze. The GeneMANIA algorithm performs as well or better than other gene function prediction methods on yeast and mouse benchmarks. The high accuracy of the GeneMANIA prediction algorithm, an intuitive user interface and large database make GeneMANIA a useful tool for any biologist.
Metrics:
Canned Analyses generated by the tool

Dataset Accession
Tool Name
Organism
Geneset
Cell Type
Disease Name
Hs Gene Symbol
Pert Type
Mm Gene Symbol
Drug Name

Interaction network and enrichment analysis of genes downregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes downregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes downregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes downregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes downregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in acute myocardial infarction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
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Datasets analyzed by the tool

Keyword
Tool Name

GSE50588
The Functional Consequences of Variation in Transcription Factor Binding
294
GSE47856
Expression data from cultured human ovarian carcinoma cell lines with and without Cisplatin treatment
119
GSE6930
Cytosine arabinoside effect on Ewing's sarcoma cell line: time course and dose response
119
GSE7002
Formaldehyde effect on nasal epithelium: dose response and time course
119
GSE490
Pharmacogenomic effect of corticosteroid in skeletal muscle
112
GSE35366
Models of Neuronal Migration Defects: time course
112
GSE47150
Embryonic primary cortical neuron response to knockdown of multiple autism candidate genes
112
GSE60413
Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
105
GSE15129
Coenzyme Q10-dependent gene expression in SAMP1 mice tissues
105
GSE18344
Nrf2-deficient lung response to cigarette smoke: dose response and time course
98
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