Interaction network and enrichment analysis of genes upregulated in MELAS syndrome
Canned Analysis
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General Information
AccessionDCA00032750
TitleInteraction network and enrichment analysis of genes upregulated in MELAS syndrome
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by MELAS syndrome and healthy control cells in the Muscle - Striated (Skeletal) (MMHCC) cell type.
Analysis URLhttp://genemania.org/#/search/human/TNNT3|EEF1A1P9|APOD|HLA-A|RPS4Y1|EEF2|LDHB|CFL1|TCAP|RPL36|FTL|ACTG1|NACAP1|SPARCL1|MYOM2|ANKRD2|SERPINF1|ETFB|NMRK2|THBS4|ATP2A1|EEF1A1|ATP1A2|COL6A3|GSTO1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:102
Cell TypeMuscle - Striated (Skeletal) (MMHCC)
DO IDDOID:3687
Disease NameMELAS syndrome
Organismhuman
UMLS CUIC0162671
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM24652, GSM24653, GSM24654
Perturbed SamplesGSM24655, GSM24656, GSM24657, GSM24658
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1462
Gene Expression Omnibus
Mitochondrial encephalomyopathies associated with mitochondrial DNA mutations
7
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