Interaction network and enrichment analysis of genes downregulated in autism spectrum disorder
Canned Analysis
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General Information
AccessionDCA00032759
TitleInteraction network and enrichment analysis of genes downregulated in autism spectrum disorder
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by autism spectrum disorder and healthy control cells in the peripheral blood lymphocytes cell type.
Analysis URLhttp://genemania.org/#/search/human/IFITM2|TXNIP|OAZ1|UBC|HLA-B|MNDA|CXCR2|DEFA1B|S100P|SH3BGRL3|TYROBP|HLA-DRB5|IFITM3|TALDO1|RPS2|CORO1A|FCGR3B|IFITM1|CFL1|CCL5|S100A9|HBA2|MSRB1|TRBC1|LINC01002
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1025
Cell Typeperipheral blood lymphocytes
DO IDDOID:0060041
Disease Nameautism spectrum disorder
Organismhuman
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM627078, GSM627090, GSM627099, GSM627105, GSM627117, GSM627121, GSM627127
Perturbed SamplesGSM627146, GSM627156, GSM627188
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25507
Gene Expression Omnibus
Autistic children and their fathers age: peripheral blood lymphocytes
84
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