Interaction network and enrichment analysis of genes downregulated in fragile X syndrome
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00032779
TitleInteraction network and enrichment analysis of genes downregulated in fragile X syndrome
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by fragile X syndrome and healthy control cells in the lymphoblastoid cells cell type.
Analysis URLhttp://genemania.org/#/search/human/CLEC4E|IGHV3-48|LAMB1|BAMBI|IGLL5|IGHV3-30|GAL3ST1|IGK|CNTFR|JAZF1|PPP1R26|VIM|LINC00937|AMICA1|BEND5|IRS1|EDNRB|CA2|IGHM|CTDSPL|SIPA1L2|IGKV1D-13|RHOU|IGHV4-31|TIMD4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvcogliani
CREEDS IDdz:515
Cell Typelymphoblastoid cells
DO IDDOID:14261
Disease Namefragile X syndrome
Organismhuman
UMLS CUIC0016667
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM176601, GSM176602, GSM176604, GSM176605, GSM176607, GSM176608, GSM176609, GSM176610, GSM176612, GSM176613, GSM176614, GSM176615, GSM176617, GSM176618, GSM176619
Perturbed SamplesGSM176505, GSM176506, GSM176507, GSM176508, GSM176509, GSM176510, GSM176535, GSM176570, GSM176575, GSM176579, GSM176583, GSM176586, GSM176589, GSM176592, GSM176594
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE7329
Gene Expression Omnibus
Autism, fragile X syndrome, and 15q11-q13 duplication: lymphoblastoid cells
33
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.