Interaction network and enrichment analysis of genes upregulated in autism spectrum disorder
Canned Analysis
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General Information
AccessionDCA00032790
TitleInteraction network and enrichment analysis of genes upregulated in autism spectrum disorder
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by autism spectrum disorder and healthy control cells in the lymphoblastoid cells cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS4X|MNDA|LOC100505937|PF4|B2M|ITM2B|RLIM|COX1|CTSS|RGS2|RPS26|RPS25|RNF149|TUBA1A|PROK2|PPBP|BCL6|FCGR3B|CXCR2|RPS4Y1|BNIP3L|LOC100134445|IFI16|MS4A1|NAMPT
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1038
Cell Typelymphoblastoid cells
DO IDDOID:0060041
Disease Nameautism spectrum disorder
Organismhuman
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM736476, GSM736477, GSM736478, GSM736479, GSM736480, GSM736481, GSM736482, GSM736483, GSM736484, GSM736485, GSM736486, GSM736487, GSM736488
Perturbed SamplesGSM736489, GSM736490
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE29691
Gene Expression Omnibus
Expression data from patients with global developmental delay and autistic features and normal controls
7
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