Interaction network and enrichment analysis of genes downregulated in myotonic dystrophy type 1
Canned Analysis
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General Information
AccessionDCA00032827
TitleInteraction network and enrichment analysis of genes downregulated in myotonic dystrophy type 1
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by myotonic dystrophy type 1 and healthy control cells in the embryonic stem cells cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS4Y1|RPL3|RPL12|RPL13A|RAN|RPL34|EEF1G|HSP90AA1|RPL11|DNMT3B|RPS21|RPL4|LDHB|EEF2|LDHA|RPL8|RAB13|EEF1B2|FAU|SNHG17|RPL36AL|ZIC2|NDUFS6|SRP14|SNHG6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1049
Cell Typeembryonic stem cells
DO IDDOID:11722
Disease Namemyotonic dystrophy type 1
Organismhuman
UMLS CUIC0027126
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM172874, GSM172875, GSM172876
Perturbed SamplesGSM172880, GSM172881, GSM172882
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE7179
Gene Expression Omnibus
Comparison of gene expression data between wild-type and DM1-affected undifferentiated hES cells.
14
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