Interaction network and enrichment analysis of genes upregulated in Down syndrome
Canned Analysis
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General Information
AccessionDCA00032860
TitleInteraction network and enrichment analysis of genes upregulated in Down syndrome
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Down syndrome and healthy control cells in the bone marrow cell type.
Analysis URLhttp://genemania.org/#/search/human/COX1|IGJ|RPS26|S100A16|CXCR4|S100A4|COX2|TCL1A|HBG2|NPIPB5|LDHA|VPREB1|IRX1|IFITM1|NFKBIZ|PRDX1|ID2|RPL13A|LAPTM5|RASD1|HERPUD1|NACA|SOD1|IFI27|CD99
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1063
Cell Typebone marrow
DO IDDOID:14250
Disease NameDown syndrome
Organismhuman
UMLS CUIC0013080
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM523117, GSM523134, GSM523135, GSM523136, GSM523137, GSM523138, GSM523139, GSM523140, GSM523141, GSM523143, GSM523144, GSM523145, GSM523146, GSM523147, GSM523148, GSM523150, GSM523151, GSM523152, GSM523153, GSM523154, GSM523157, GSM523158, GSM523160, GS
Perturbed SamplesGSM523115, GSM523116, GSM523118, GSM523119, GSM523120, GSM523121, GSM523122, GSM523123, GSM523124, GSM523125, GSM523126, GSM523127, GSM523128, GSM523129, GSM523130, GSM523131, GSM523132, GSM523133, GSM523142, GSM523149, GSM523155, GSM523156, GSM523159
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20910
Gene Expression Omnibus
Expression data from Down syndrome and non-Down syndrome pediatric acute lymphoblastic leukemia cases
7
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