Interaction network and enrichment analysis of genes downregulated in sickle cell anemia
Canned Analysis
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General Information
AccessionDCA00032887
TitleInteraction network and enrichment analysis of genes downregulated in sickle cell anemia
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by sickle cell anemia and healthy control cells in the Endothelial cell cell type.
Analysis URLhttp://genemania.org/#/search/human/TMSB4XP8|LOC728026|BMP4|MEST|HIST1H4C|TAGLN|PTMA
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:109
Cell TypeEndothelial cell
DO IDDOID:10923
Disease Namesickle cell anemia
Organismhuman
UMLS CUIC0002895
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM249425, GSM249426, GSM249427, GSM249428, GSM249429, GSM249430, GSM249431, GSM249432, GSM249433, GSM249434, GSM249435, GSM249436, GSM249437, GSM249438, GSM249439, GSM249440, GSM249441, GSM249442, GSM249443, GSM249444, GSM249445, GSM249446, GSM249447, GS
Perturbed SamplesGSM249452, GSM249453, GSM249454, GSM249455, GSM249456, GSM249457, GSM249458, GSM249459, GSM249460, GSM249461, GSM249462, GSM249463, GSM249464, GSM249465, GSM249466, GSM249467, GSM249468, GSM249469, GSM249470, GSM249471
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9877
Gene Expression Omnibus
Genetic Endothelial Systems Biology of Sickle Stroke Risk
7
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