Interaction network and enrichment analysis of genes upregulated in Werdnig-Hoffmann disease
Canned Analysis
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General Information
AccessionDCA00032922
TitleInteraction network and enrichment analysis of genes upregulated in Werdnig-Hoffmann disease
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Werdnig-Hoffmann disease and healthy control cells in the CNS - Spinal Cord (MMHCC) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Serpine2|Basp1|Rtn1|Rpl31-ps17|Rps2|Fabp7|Rgs17|Slc25a3|Gm3601|Rps5|Rbm3|Rplp0|Rplp2|Nnat|Rps2-ps6|6330403K07Rik|Rpl10a|Gm12191|Gm10260|Cspg5|Nrep|Rps29|Msmo1|Gnb2|Vdac3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:126
Cell TypeCNS - Spinal Cord (MMHCC)
DO IDDOID:13137
Disease NameWerdnig-Hoffmann disease
Organismmouse
UMLS CUIC0043116
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM67523, GSM67524, GSM67525
Perturbed SamplesGSM67526, GSM67529, GSM67530
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3075
Gene Expression Omnibus
Neuromuscular degeneration mutant spinal cord response to neural stem cell transplantation
12
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