Interaction network and enrichment analysis of genes downregulated in prostate cancer
Canned Analysis
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General Information
AccessionDCA00032937
TitleInteraction network and enrichment analysis of genes downregulated in prostate cancer
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by prostate cancer and healthy control cells in the Normal prostate epithelial cells and Primary epithelial cell culture (Gleason 7 score tumor) cell type.
Analysis URLhttp://genemania.org/#/search/human/IGFBP2|TFRC|GREM1|COL15A1|PABPC3|RPS2|FSTL1|SMPDL3A|RPL19|RLIM|FTH1P5|MFAP4|RPSA|DYNLL1|EEF2|MXRA7|LGALS3BP|MMP2|CTSB|TUBA1A|HIF1A|RHOA|TXNRD1|CEMIP|LXN
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:639
Cell TypeNormal prostate epithelial cells and Primary epithelial cell culture (Gleason 7 score tumor)
DO IDDOID:10283
Disease Nameprostate cancer
Organismhuman
UMLS CUIC0376358
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM88407, GSM88408
Perturbed SamplesGSM88351, GSM88360, GSM88389, GSM88390, GSM88391, GSM88392, GSM88393, GSM88394, GSM88395, GSM88396, GSM88398, GSM88399, GSM88400, GSM88403, GSM88404, GSM88405, GSM88406
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3868
Gene Expression Omnibus
Primary epithelial cell cultures from prostate tumors
21
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