Interaction network and enrichment analysis of genes downregulated in nemaline myopathy
Canned Analysis
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General Information
AccessionDCA00032995
TitleInteraction network and enrichment analysis of genes downregulated in nemaline myopathy
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by nemaline myopathy and healthy control cells in the Tibialis Muscle cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Myl1|Atp2a1|Cox6a2|Tpt1|Eno3|Acta1|Ldha|Aldoa|Tnnt3|Eef1a2|Ubb|Pvalb|Pfkm|Ndufb5|Ryr1|Cox7c|Gng5|Hba-a1|Myh1|Pkm|Slc25a4|Pgam2|Pgm2|Gbas|Pygm
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:317
Cell TypeTibialis Muscle
DO IDDOID:3191
Disease Namenemaline myopathy
Organismmouse
UMLS CUIC0206157
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM76375, GSM76376, GSM76377, GSM76378
Perturbed SamplesGSM76379, GSM76380, GSM76381, GSM76382
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3384
Gene Expression Omnibus
Nemaline myopathy model: various skeletal muscles
70
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