Interaction network and enrichment analysis of genes downregulated in severe acute respiratory syndrome
Canned Analysis
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General Information
AccessionDCA00033019
TitleInteraction network and enrichment analysis of genes downregulated in severe acute respiratory syndrome
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by severe acute respiratory syndrome and healthy control cells in the Peripheral blood mononuclear cell cell type.
Analysis URLhttp://genemania.org/#/search/human/DUSP1|FOS|CTSS|HSPA8|SELL|TNFSF10|IFITM1|RNASET2|RPS26|IL18RAP|FAM65B|RPS5|XIST|DAZAP2|SRSF5|TCF7|PLSCR1|RPL14|HBD|HLA-DRA|ISG15|CRLF3|FOLR3|RPL5|ITM2B
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:165
Cell TypePeripheral blood mononuclear cell
DO IDDOID:2945
Disease Namesevere acute respiratory syndrome
Organismhuman
UMLS CUIC1175175
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM30361, GSM30362, GSM30363, GSM30364
Perturbed SamplesGSM30365, GSM30366, GSM30367, GSM30368, GSM30369, GSM30370, GSM30371, GSM30372, GSM30373, GSM30374
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1739
Gene Expression Omnibus
Severe acute respiratory syndrome expression profile
7
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