Interaction network and enrichment analysis of genes upregulated in CHRNA4 KD
Canned Analysis
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General Information
AccessionDCA00033028
TitleInteraction network and enrichment analysis of genes upregulated in CHRNA4 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between CHRNA4 KD cells and control cells in the whole brain (mutation alpha7 +/T ) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ckb|Ptms|Gm16409|Hba-a1|Rnf10|Mt3|Pcsk1n|Rpl13|Rps2|Ywhaz|Bsg|App|Calm3|Rabac1|Rplp0|Uqcrq|Ndufv1|Hmgn1|Tuba1b|Fth1|Gabarapl1|Ubb|Clptm1|Atp6v0c|Dnm1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1724
Cell Typewhole brain (mutation alpha7 +/T )
Gene Symbol (human)CHRNA4
Gene Symbol (mouse)Chrna4
Organismmouse
Perturbation TypeKD
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM153512, GSM153526, GSM153527, GSM153528, GSM153532, GSM153533
Perturbed SamplesGSM153537, GSM153538, GSM153539, GSM153560, GSM153561
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6614
Gene Expression Omnibus
Seizure model: brain
21
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