Interaction network and enrichment analysis of genes upregulated in type 1 diabetes mellitus
Canned Analysis
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General Information
AccessionDCA00033038
TitleInteraction network and enrichment analysis of genes upregulated in type 1 diabetes mellitus
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by type 1 diabetes mellitus and healthy control cells in the Splenic Tissue cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Amy1|Cela2a|Reg1|Prss2|Ahsp|Car2|Rnase1|Cel|Amy2a5|Dmbt1|Sycn|Hmbs|Cd24a|Slc7a5|Ctse|Mki67|Tfrc|Tff2|Slc4a1|Ccl19|Alad|Birc5|Rhag|Abt1|LOC100036540
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:173
Cell TypeSplenic Tissue
DO IDDOID:9744
Disease Nametype 1 diabetes mellitus
Organismmouse
UMLS CUIC0011854
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM587, GSM588, GSM594, GSM595
Perturbed SamplesGSM582, GSM589
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11
Gene Expression Omnibus
Type 1 diabetes gene expression profiling
14
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