Interaction network and enrichment analysis of genes downregulated in atherosclerosis
Canned Analysis
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General Information
AccessionDCA00033075
TitleInteraction network and enrichment analysis of genes downregulated in atherosclerosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by atherosclerosis and healthy control cells in the Hepatic Tissue cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Cyp1a2|Cyp3a16|Mug-ps1|Alas1|Selenbp1|Ldlr|Mup19|Cyp2d12|Inmt|Errfi1|Gc|B2m|Adh1|Cyp4a12b|Tdo2|Scp2|Cyp4v3|Cyp2e1|Gm19491|Ugt2b5|Cfhr1|C9|Eef1a1|Rpl41|LOC676708
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:193
Cell TypeHepatic Tissue
DO IDDOID:1936
Disease Nameatherosclerosis
Organismmouse
UMLS CUIC0004153
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM5403, GSM5404, GSM5405, GSM5406, GSM5407, GSM5408
Perturbed SamplesGSM5409, GSM5410, GSM5411, GSM5412, GSM5413, GSM5414
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE363
Gene Expression Omnibus
Diet induced changes in liver
7
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