Interaction network and enrichment analysis of genes upregulated in chronic lymphocytic leukemia
Canned Analysis
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General Information
AccessionDCA00033078
TitleInteraction network and enrichment analysis of genes upregulated in chronic lymphocytic leukemia
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by chronic lymphocytic leukemia and healthy control cells in the Peripheral blood mononuclear cell cell type.
Analysis URLhttp://genemania.org/#/search/human/NFKBIA|HLA-DRB1|HLA-DRB4|HLA-DRB5|CD74|EEF1G|HLA-DRA|HBB|HBA2|EEF2|RPS26|VOPP1|TNFAIP3|RPL12|RPS9|RPL7A|RPS15|RPS2|RPS4X|CDC42SE1|RPS8|HLA-DMA|FAIM3|RPL26|RPSA
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:194
Cell TypePeripheral blood mononuclear cell
DO IDDOID:1040
Disease Namechronic lymphocytic leukemia
Organismhuman
UMLS CUIC0023458
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM219478, GSM219479, GSM219480, GSM219481, GSM219482, GSM219483, GSM219484, GSM219485, GSM219486, GSM219487, GSM219488, GSM219489, GSM219510, GSM219511, GSM219512, GSM219513, GSM219514, GSM219515, GSM219516, GSM219517, GSM219518, GSM219519, GSM219520, GS
Perturbed SamplesGSM219456, GSM219457, GSM219458, GSM219459, GSM219460, GSM219461, GSM219462, GSM219463, GSM219464, GSM219465, GSM219466, GSM219467, GSM219468, GSM219469, GSM219470, GSM219471, GSM219472, GSM219473, GSM219474, GSM219475, GSM219476, GSM219477, GSM219490, GS
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8835
Gene Expression Omnibus
Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.
7
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