Interaction network and enrichment analysis of genes upregulated in mental depression
Canned Analysis
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General Information
AccessionDCA00033182
TitleInteraction network and enrichment analysis of genes upregulated in mental depression
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by mental depression and healthy control cells in the Prefrontal Cortex cell type.
Analysis URLhttp://genemania.org/#/search/human/GFAP|HBA2|HBB|HMGN2|IFITM3|RPL37A|ENC1|EEF1A1|PTGDS|FAM107A|LOC100505584|RTN4|HSP90AA1|CLU|MBP|MT1E|VIM|GABARAP|TUBA1B|TUBB2B|UBB|RPS28|CAMK2A|COX7C|RPL41
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdz:462
Cell TypePrefrontal Cortex
DO IDDOID:1596
Disease Namemental depression
Organismhuman
UMLS CUIC0011570
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM317649, GSM317652, GSM317666, GSM317672, GSM317679, GSM317681, GSM317682, GSM317683, GSM317689, GSM317691, GSM317692, GSM317693, GSM317696, GSM317697, GSM317698
Perturbed SamplesGSM317650, GSM317651, GSM317657, GSM317667, GSM317670, GSM317674, GSM317675, GSM317677, GSM317678, GSM317687, GSM317695
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12654
Gene Expression Omnibus
Various mental disorders: postmortem brains
26
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