Interaction network and enrichment analysis of genes downregulated in primary open angle glaucoma
Canned Analysis
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General Information
AccessionDCA00033251
TitleInteraction network and enrichment analysis of genes downregulated in primary open angle glaucoma
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by primary open angle glaucoma and healthy control cells in the Optic Disk cell type.
Analysis URLhttp://genemania.org/#/search/human/FTL|PABPC1|EEF1A1|RND3|PPP1R3C|EIF4A2|TMSB4XP8|PFN2|AKR1C2|RPL13A|TXNRD1|B2M|IFITM3|RPS18|RPL41|RPL23A|LGALS3|RGS4|RPS23|S100A6|ANXA1|RPL30|FTH1|NGFRAP1|RPS15A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:257
Cell TypeOptic Disk
DO IDDOID:1070
Disease Nameprimary open angle glaucoma
Organismhuman
UMLS CUIC0339573
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM52089, GSM52091
Perturbed SamplesGSM52088, GSM52090
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2705
Gene Expression Omnibus
GFAP-negative lamina cribrosa cell response to TGF-beta1
7
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