Interaction network and enrichment analysis of genes upregulated in familial combined hyperlipidemia
Canned Analysis
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General Information
AccessionDCA00033268
TitleInteraction network and enrichment analysis of genes upregulated in familial combined hyperlipidemia
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by familial combined hyperlipidemia and healthy control cells in the Blood monocyte cell type.
Analysis URLhttp://genemania.org/#/search/human/HBA2|HLA-DRB4|HLA-DPB1|HBB|FCN1|HLA-DRB5|CD14|GPX1|HLA-DQA2|LGALS1|SPP1|LOC100133583|TGFBI|C3AR1|TMSB10|CXCL10|HLA-DRA|NPC2|HSPA5|ATP10D|CST3|LTA4H|HLA-DRB1|ATP6V1F|THBS1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:267
Cell TypeBlood monocyte
DO IDDOID:13809
Disease Namefamilial combined hyperlipidemia
Organismhuman
UMLS CUIC0020474
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM287664, GSM287665, GSM287666
Perturbed SamplesGSM287667, GSM287668, GSM287669, GSM287670, GSM287671, GSM287672
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11393
Gene Expression Omnibus
Atorvastatin treatment of familial combined hyperlipidemia: peripheral blood monocytes
28
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