Interaction network and enrichment analysis of genes upregulated following Atorvastatin treatment
Canned Analysis
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General Information
AccessionDCA00033272
TitleInteraction network and enrichment analysis of genes upregulated following Atorvastatin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Atorvastatin treated cells and untreated control cells in the Peripheral blood monocytes cell type.
Analysis URLhttp://genemania.org/#/search/human/S100A9|DEFA1B|IFITM3|IFITM2|HBA2|TMSB10|CXCL8|HBB|RGS2|C3AR1|FCN1|IL1B|DENND5A|PPIF|OLR1|PLBD1|BCL2A1|NOTCH2NL|ZMIZ1|ITGB2|HLA-DRB4|CST3|G0S2|NINJ1|SAT1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3196
Cell TypePeripheral blood monocytes
Drug NameAtorvastatin
DrugBank IDDB01076
Organismhuman
SMILES IDOC(CC(CC(=O)[O-])O)CCn1c(C(C)C)c(c(c1c1ccc(cc1)F)c1ccccc1)C(=O)Nc1ccccc1
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM287667, GSM287668, GSM287669
Perturbed SamplesGSM287670, GSM287671, GSM287672
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11393
Gene Expression Omnibus
Atorvastatin treatment of familial combined hyperlipidemia: peripheral blood monocytes
28
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